Binase Immobilized on Halloysite Nanotubes Exerts Enhanced Cytotoxicity toward Human Colon Adenocarcinoma Cells

Binase Immobilized on Halloysite Nanotubes Exerts Enhanced Cytotoxicity toward Human Colon Adenocarcinoma Cells

Many ribonucleases (RNases) are considered as promising tools for antitumor therapy because of their selective cytotoxicity toward cancer cells. Binase, the RNase from Bacillus pumilus, triggers apoptotic response in cancer cells expressing RAS oncogene which is mutated in a large percentage of prev...

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Bibliographic Details
Main Authors: Vera Khodzhaeva, Anna Makeeva, Vera Ulyanova, Pavel Zelenikhin, Vladimir Evtugyn, Martin Hardt, Elvira Rozhina, Yuri Lvov, Rawil Fakhrullin, Olga Ilinskaya
Format: Article
Language:English
Published: Frontiers Media S.A. 2017-09-01
Series:Frontiers in Pharmacology
Subjects:
Bacillus pumilus
RNase
binase
halloysite
nanotubes
colon adenocarcinoma
Online Access:http://journal.frontiersin.org/article/10.3389/fphar.2017.00631/full

Internet

http://journal.frontiersin.org/article/10.3389/fphar.2017.00631/full

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