Suppression of MMP-2 attenuates TNF-α induced NF-κB activation and leads to JNK mediated cell death in glioma.

Suppression of MMP-2 attenuates TNF-α induced NF-κB activation and leads to JNK mediated cell death in glioma.

Abrogation of apoptosis for prolonged cell survival is essential in cancer progression. In our previous studies, we showed the MMP-2 downregulation induced apoptosis in cancer cell lines. Here, we attempt to investigate the exact molecular mechanism of how MMP-2 depletion leads to apoptosis in gliom...

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Bibliographic Details
Main Authors: Divya Kesanakurti, Chandramu Chetty, Praveen Bhoopathi, Sajani S Lakka, Bharathi Gorantla, Andrew J Tsung, Jasti S Rao
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2011-05-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3087754?pdf=render

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http://europepmc.org/articles/PMC3087754?pdf=render

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