Soluble Dipeptidyl Peptidase-4 Induces Fibroblast Activation Through Proteinase-Activated Receptor-2

Soluble Dipeptidyl Peptidase-4 Induces Fibroblast Activation Through Proteinase-Activated Receptor-2

Fibroblasts are the chief secretory cells of the extracellular matrix (ECM) responsible for basal deposition and degradation of the ECM under normal conditions. During stress, fibroblasts undergo continuous activation, which is defined as the differentiation of fibroblasts into myofibroblasts, a cel...

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Bibliographic Details
Main Authors: Shih-Yi Lee, Shao-Tung Wu, Yao-Jen Liang, Ming-Jai Su, Cheng-Wei Huang, Yu-Hsuan Jao, Hui-Chun Ku
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-09-01
Series:Frontiers in Pharmacology
Subjects:
dipeptidyl peptidase-4
fibrosis
fibroblast
proteinase-activated receptor-2
nuclear factor-kappa B
suppressor of mothers against decapentaplegic
Online Access:https://www.frontiersin.org/article/10.3389/fphar.2020.552818/full

Internet

https://www.frontiersin.org/article/10.3389/fphar.2020.552818/full

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