WDR5 inhibition halts metastasis dissemination by repressing the mesenchymal phenotype of breast cancer cells

WDR5 inhibition halts metastasis dissemination by repressing the mesenchymal phenotype of breast cancer cells

Abstract Background Development of metastases and drug resistance are still a challenge for a successful systemic treatment in breast cancer (BC) patients. One of the mechanisms that confer metastatic properties to the cell relies in the epithelial-to-mesenchymal transition (EMT). Moreover, both EMT...

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Bibliographic Details
Main Authors: Simona Punzi, Chiara Balestrieri, Carolina D’Alesio, Daniela Bossi, Gaetano Ivan Dellino, Elena Gatti, Giancarlo Pruneri, Carmen Criscitiello, Giulia Lovati, Marine Meliksetyan, Alessandro Carugo, Giuseppe Curigliano, Gioacchino Natoli, Pier Giuseppe Pelicci, Luisa Lanfrancone
Format: Article
Language:English
Published: BMC 2019-11-01
Series:Breast Cancer Research
Subjects:
Breast cancer
EMT
Metastasis
TGFβ1
WDR5
Online Access:http://link.springer.com/article/10.1186/s13058-019-1216-y

Internet

http://link.springer.com/article/10.1186/s13058-019-1216-y

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