A region-based gene association study combined with a leave-one-out sensitivity analysis identifies SMG1 as a pancreatic cancer susceptibility gene.

A region-based gene association study combined with a leave-one-out sensitivity analysis identifies SMG1 as a pancreatic cancer susceptibility gene.

Pancreatic adenocarcinoma (PC) is a lethal malignancy that is familial or associated with genetic syndromes in 10% of cases. Gene-based surveillance strategies for at-risk individuals may improve clinical outcomes. However, familial PC (FPC) is plagued by genetic heterogeneity and the genetic basis...

Full description

Bibliographic Details
Main Authors: Cavin Wong, Fei Chen, Najmeh Alirezaie, Yifan Wang, Adeline Cuggia, Ayelet Borgida, Spring Holter, Tatiana Lenko, Celine Domecq, Alzheimer’s Disease Neuroimaging Initiative, Gloria M Petersen, Sapna Syngal, Randall Brand, Anil K Rustgi, Michele L Cote, Elena Stoffel, Sara H Olson, Nicholas J Roberts, Mohammad R Akbari, Jacek Majewski, Alison P Klein, Celia M T Greenwood, Steven Gallinger, George Zogopoulos
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2019-08-01
Series:PLoS Genetics
Online Access:https://doi.org/10.1371/journal.pgen.1008344

Internet

https://doi.org/10.1371/journal.pgen.1008344

Similar Items