Disruption of a Quorum Sensing mechanism triggers tumorigenesis: a simple discrete model corroborated by experiments in mammary cancer stem cells

<p>Abstract</p> <p>Background</p> <p>The balance between self-renewal and differentiation of stem cells is expected to be tightly controlled in order to maintain tissue homeostasis throughout life, also in the face of environmental hazards. Theory, predicting that homeo...

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Bibliographic Details
Main Authors: Kirnasovsky Oleg U, Lamb Rebecca, Harrison Hannah, Levi Liora, Kogan Yuri, Agur Zvia, Clarke Robert B
Format: Article
Language:English
Published: BMC 2010-04-01
Series:Biology Direct
Online Access:http://www.biology-direct.com/content/5/1/20