Severity of Demyelinating and Axonal Neuropathy Mouse Models Is Modified by Genes Affecting Structure and Function of Peripheral Nodes

Severity of Demyelinating and Axonal Neuropathy Mouse Models Is Modified by Genes Affecting Structure and Function of Peripheral Nodes

Charcot-Marie-Tooth (CMT) disease is a clinically and genetically heterogeneous group of inherited polyneuropathies. Mutations in 80 genetic loci can cause forms of CMT, resulting in demyelination and axonal dysfunction. The clinical presentation, including sensory deficits, distal muscle weakness,...

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Bibliographic Details
Main Authors: Kathryn H. Morelli, Kevin L. Seburn, David G. Schroeder, Emily L. Spaulding, Loiuse A. Dionne, Gregory A. Cox, Robert W. Burgess
Format: Article
Language:English
Published: Elsevier 2017-03-01
Series:Cell Reports
Subjects:
axons
length constant
degeneration
genetic modifiers
Charcot-Marie-Tooth disease
hereditary sensory
motor neuropathy
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124717303261

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http://www.sciencedirect.com/science/article/pii/S2211124717303261

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