Silencing Srsf6 does not modulate incomplete splicing of the huntingtin gene in Huntington’s disease models
Abstract We have previously shown that the incomplete splicing of exon 1 to exon 2 of the HTT gene results in the production of a small polyadenylated transcript (Httexon1) that encodes the highly pathogenic exon 1 HTT protein. There is evidence to suggest that the splicing factor SRSF6 is involved...
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Nature Publishing Group
2020-08-01
|
| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-020-71111-w |