Silencing Srsf6 does not modulate incomplete splicing of the huntingtin gene in Huntington’s disease models
Abstract We have previously shown that the incomplete splicing of exon 1 to exon 2 of the HTT gene results in the production of a small polyadenylated transcript (Httexon1) that encodes the highly pathogenic exon 1 HTT protein. There is evidence to suggest that the splicing factor SRSF6 is involved...
Main Authors: | Michael A. Mason, Casandra Gomez-Paredes, Kirupa Sathasivam, Andreas Neueder, Aikaterini-Smaragdi Papadopoulou, Gillian P. Bates |
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Format: | Article |
Language: | English |
Published: |
Nature Publishing Group
2020-08-01
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Series: | Scientific Reports |
Online Access: | https://doi.org/10.1038/s41598-020-71111-w |
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