Enhanced HSC-like cell generation from mouse pluripotent stem cells in a 3D induction system cocultured with stromal cells

Enhanced HSC-like cell generation from mouse pluripotent stem cells in a 3D induction system cocultured with stromal cells

Abstract Background Decades of efforts have attempted to differentiate the pluripotent stem cells (PSCs) into truly functional hematopoietic stem cells (HSCs), yet the problems of low differentiation efficiency in vitro and poor hematopoiesis reconstitution in vivo still exist, mainly attributing to...

Full description

Bibliographic Details
Main Authors: Wei Shan, Qin Yu, Yan Long, Qian Luo, Honghu Li, Yingli Han, Yulin Xu, Shan Fu, Xiangjun Zeng, Cong Wei, Yang Gao, Xiaoqing Li, Xia Li, Lifei Zhang, Lizhen Liu, Ming Chen, Pengxu Qian, He Huang
Format: Article
Language:English
Published: BMC 2021-06-01
Series:Stem Cell Research & Therapy
Subjects:
3D system
Pluripotent stem cells
Hematopoiesis
CD201
Notch
Online Access:https://doi.org/10.1186/s13287-021-02434-2

Internet

https://doi.org/10.1186/s13287-021-02434-2

Similar Items