Peripheral PD-1+ T Cells Co-expressing Inhibitory Receptors Predict SVR With Ultra Short Duration DAA Therapy in HCV Infection

Peripheral PD-1+ T Cells Co-expressing Inhibitory Receptors Predict SVR With Ultra Short Duration DAA Therapy in HCV Infection

Direct acting antiviral (DAA) regimens of 12 weeks result in HCV clearance in vast majority of patients across genotypes. We previously demonstrated an ultra-short regimen of 4 weeks DAA cleared HCV in a subset of patients. Here, we hypothesized that individual level of antiviral immunity differenti...

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Bibliographic Details
Main Authors: Sara Romani, Kristen Stafford, Amy Nelson, Shashwatee Bagchi, Shyam Kottilil, Bhawna Poonia
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-06-01
Series:Frontiers in Immunology
Subjects:
chronic HCV
PD-1
relapse
4 week DAA therapy
immune response
short-duration DAA
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2019.01470/full

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https://www.frontiersin.org/article/10.3389/fimmu.2019.01470/full

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