Alpha-synuclein deregulates the expression of COL4A2 and impairs ER-Golgi function

Alpha-synuclein deregulates the expression of COL4A2 and impairs ER-Golgi function

Alpha-synuclein (aSyn) is the major protein component of Lewy bodies and Lewy neurites, the typical pathological hallmarks in Parkinson's disease (PD) and Dementia with Lewy bodies. aSyn is capable of inducing transcriptional deregulation, but the precise effect of specific aSyn mutants associa...

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Bibliographic Details
Main Authors: Isabel Paiva, Gaurav Jain, Diana F. Lázaro, Kristina Gotovac Jerčić, Thomas Hentrich, Cemil Kerimoglu, Raquel Pinho, Èva M. Szegő, Susanne Burkhardt, Vincenzo Capece, Rashi Halder, Rezaul Islam, Mary Xylaki, Lucas A. Caldi Gomes, Anna-Elisa Roser, Paul Lingor, Julia M. Schulze-Hentrich, Fran Borovečki, André Fischer, Tiago F. Outeiro
Format: Article
Language:English
Published: Elsevier 2018-11-01
Series:Neurobiology of Disease
Subjects:
A30P alpha-synuclein
COL4A2
ER stress
Golgi fragmentation
Transcription deregulation
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996118303929

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http://www.sciencedirect.com/science/article/pii/S0969996118303929

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