Targeting Super‐Enhancers via Nanoparticle‐Facilitated BRD4 and CDK7 Inhibitors Synergistically Suppresses Pancreatic Ductal Adenocarcinoma

Targeting Super‐Enhancers via Nanoparticle‐Facilitated BRD4 and CDK7 Inhibitors Synergistically Suppresses Pancreatic Ductal Adenocarcinoma

Abstract Pancreatic ductal adenocarcinoma (PDAC) is a lethal malignant cancer with complex genomic variations, and no targetable genomic lesions have been found yet. Super‐enhancers (SEs) have been found to contribute to the continuous and robust oncogenic transcription. Here, histone H3 lysine 27 a...

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Bibliographic Details
Main Authors: Chen‐Song Huang, Xinru You, Chunlei Dai, Qiong‐Cong Xu, Fuxi Li, Li Wang, Xi‐Tai Huang, Jie‐Qin Wang, Shi‐Jin Li, Zhuoxing Gao, Jun Wu, Xiao‐Yu Yin, Wei Zhao
Format: Article
Language:English
Published: Wiley 2020-04-01
Series:Advanced Science
Subjects:
BRD4
CDK7
nanoparticles
pancreatic ductal adenocarcinoma
super enhancers
Online Access:https://doi.org/10.1002/advs.201902926

Internet

https://doi.org/10.1002/advs.201902926

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