Different curcumin forms selectively bind fibrillar amyloid beta in post mortem Alzheimer’s disease brains: Implications for in-vivo diagnostics

Different curcumin forms selectively bind fibrillar amyloid beta in post mortem Alzheimer’s disease brains: Implications for in-vivo diagnostics

Abstract The combined fluorescent and Aβ-binding properties of the dietary spice curcumin could yield diagnostic purpose in the search for a non-invasive Aβ-biomarker for Alzheimer’s disease (AD). However, evidence on the binding properties of curcumin, its conjugates and clinically used bio-availab...

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Bibliographic Details
Main Authors: Jurre den Haan, Tjado H. J. Morrema, Annemieke J. Rozemuller, Femke H. Bouwman, Jeroen J. M. Hoozemans
Format: Article
Language:English
Published: BMC 2018-08-01
Series:Acta Neuropathologica Communications
Subjects:
Curcumin
Amyloid-beta
Alzheimer’s disease
Cerebral amyloid angiopathy (CAA)
Neurodegeneration
Biomarker
Online Access:http://link.springer.com/article/10.1186/s40478-018-0577-2

Internet

http://link.springer.com/article/10.1186/s40478-018-0577-2

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