Transgenic tomatoes expressing the 6F peptide and ezetimibe prevent diet-induced increases of IFN-β and cholesterol 25-hydroxylase in jejunum

Transgenic tomatoes expressing the 6F peptide and ezetimibe prevent diet-induced increases of IFN-β and cholesterol 25-hydroxylase in jejunum

Feeding LDL receptor (LDLR)-null mice a Western diet (WD) increased the expression of IFN-β in jejunum as determined by quantitative RT-PCR (RT-qPCR), immunohistochemistry (IHC), and ELISA (all P < 0.0001). WD also increased the expression of cholesterol 25-hydroxylase (CH25H) as measured by RT-q...

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Bibliographic Details
Main Authors: Pallavi Mukherjee, Greg Hough, Arnab Chattopadhyay, Mohamad Navab, Hannah R. Fogelman, David Meriwether, Kevin Williams, Steven Bensinger, Travis Moller, Kym F. Faull, Aldons J. Lusis, M. Luisa Iruela-Arispe, Kristina I. Bostrom, Peter Tontonoz, Srinivasa T. Reddy, Alan M. Fogelman
Format: Article
Language:English
Published: Elsevier 2017-08-01
Series:Journal of Lipid Research
Subjects:
apolipoprotein A-I mimetic peptides
ather­osclerosis
hyperlipidemia
oxysterols
Online Access:http://www.sciencedirect.com/science/article/pii/S0022227520337895

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http://www.sciencedirect.com/science/article/pii/S0022227520337895

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