Role of Nfu1 and Bol3 in iron-sulfur cluster transfer to mitochondrial clients

Iron-sulfur (Fe-S) clusters are essential for many cellular processes, ranging from aerobic respiration, metabolite biosynthesis, ribosome assembly and DNA repair. Mutations in NFU1 and BOLA3 have been linked to genetic diseases with defects in mitochondrial Fe-S centers. Through genetic studies in...

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Bibliographic Details
Main Authors: Andrew Melber, Un Na, Ajay Vashisht, Benjamin D Weiler, Roland Lill, James A Wohlschlegel, Dennis R Winge
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2016-08-01
Series:eLife
Subjects:
Online Access:https://elifesciences.org/articles/15991