Structure of a stapled peptide antagonist bound to nutlin-resistant Mdm2.

Structure of a stapled peptide antagonist bound to nutlin-resistant Mdm2.

As key negative regulator of the p53 tumour suppressor, Mdm2 is an attractive therapeutic target. Small molecules such as Nutlin have been developed to antagonise Mdm2, resulting in p53-dependent death of tumour cells. We have recently described a mutation in Mdm2 (M62A), which precludes binding of...

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Bibliographic Details
Main Authors: Sharon Min Qi Chee, Jantana Wongsantichon, Quah Soo Tng, Robert Robinson, Thomas L Joseph, Chandra Verma, David P Lane, Christopher J Brown, Farid J Ghadessy
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4130638?pdf=render

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http://europepmc.org/articles/PMC4130638?pdf=render

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