Therapeutic Targeting of Retinal Immune Microenvironment With CSF-1 Receptor Antibody Promotes Visual Function Recovery After Ischemic Optic Neuropathy

Therapeutic Targeting of Retinal Immune Microenvironment With CSF-1 Receptor Antibody Promotes Visual Function Recovery After Ischemic Optic Neuropathy

Retinal ischemia/reperfusion injury (RI) is a common cause of irreversible visual impairment and blindness in elderly and critical unmet medical need. While no effective treatment is available for RI, microglial activation and local immune responses in the retina are thought to play important roles...

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Bibliographic Details
Main Authors: Yizhen Tang, Zebin Xiao, Li Pan, Dongli Zhuang, Kin-Sang Cho, Kyle Robert, Xiaoxiao Chen, Lian Shu, Guangxian Tang, Jihong Wu, Xinghuai Sun, Dong F. Chen
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-11-01
Series:Frontiers in Immunology
Subjects:
visual acuity
retinal ganglion cell
neurodegeneration
retinal ischemia/reperfusion
colony stimulating factor-1
microglia
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2020.585918/full

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https://www.frontiersin.org/articles/10.3389/fimmu.2020.585918/full

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