The ADMR receptor mediates the effects of adrenomedullin on pancreatic cancer cells and on cells of the tumor microenvironment.

Adrenomedullin (AM) is highly expressed in pancreatic cancer and stimulates pancreatic cancer cells leading to increased tumor growth and metastasis. The current study examines the role of specific AM receptors on tumor and cells resembling the tumor microenvironment (human pancreatic stellate--HPSC...

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Bibliographic Details
Main Authors: Vijaya Ramachandran, Thiruvengadam Arumugam, Robert Langley, Rosa F Hwang, Pablo Vivas-Mejia, Anil K Sood, Gabriel Lopez-Berestein, Craig D Logsdon
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2009-10-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC2760778?pdf=render