Mass spectrometry-directed structure elucidation and total synthesis of ultra-long chain (O-acyl)-ω-hydroxy fatty acids

Mass spectrometry-directed structure elucidation and total synthesis of ultra-long chain (O-acyl)-ω-hydroxy fatty acids

The (O-acyl)-ω-hydroxy FAs (OAHFAs) comprise an unusual lipid subclass present in the skin, vernix caseosa, and meibomian gland secretions. Although they are structurally related to the general class of FA esters of hydroxy FAs (FAHFAs), the ultra-long chain (30–34 carbons) and the putative ω-substi...

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Bibliographic Details
Main Authors: Sarah E. Hancock, Ramesh Ailuri, David L. Marshall, SimonH.J. Brown, Jennifer T. Saville, Venkateswara R. Narreddula, Nathan R. Boase, BerwyckL.J. Poad, Adam J. Trevitt, MarkD.P. Willcox, Michael J. Kelso, Todd W. Mitchell, Stephen J. Blanksby
Format: Article
Language:English
Published: Elsevier 2018-08-01
Series:Journal of Lipid Research
Subjects:
tandem mass spectrometry
chemical synthesis
eye
secretion
fatty acid esters of hydroxy fatty acids
meibum
Online Access:http://www.sciencedirect.com/science/article/pii/S0022227520330601

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http://www.sciencedirect.com/science/article/pii/S0022227520330601

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