PRV UL13 inhibits cGAS–STING-mediated IFN-β production by phosphorylating IRF3

PRV UL13 inhibits cGAS–STING-mediated IFN-β production by phosphorylating IRF3

Abstract Cyclic GMP-AMP (cGAMP) synthase (cGAS) is an intracellular sensor of cytoplasmic viral DNA created during virus infection, which subsequently activates the stimulator of interferon gene (STING)-dependent type I interferon response to eliminate pathogens. In contrast, viruses have developed...

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Bibliographic Details
Main Authors: Zongyi Bo, Yurun Miao, Rui Xi, Qiuping Zhong, Chenyi Bao, Huan Chen, Liumei Sun, Yingjuan Qian, Yong-Sam Jung, Jianjun Dai
Format: Article
Language:English
Published: BMC 2020-09-01
Series:Veterinary Research
Subjects:
pseudorabies virus
cGAS–STING
UL13 serine/threonine kinase protein
IRF3
Online Access:http://link.springer.com/article/10.1186/s13567-020-00843-4

Internet

http://link.springer.com/article/10.1186/s13567-020-00843-4

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