NMDA receptor-mediated CaMKII/ERK activation contributes to renal fibrosis

NMDA receptor-mediated CaMKII/ERK activation contributes to renal fibrosis

Abstract Background This study aimed to understand the mechanistic role of N-methyl-D-aspartate receptor (NMDAR) in acute fibrogenesis using models of in vivo ureter obstruction and in vitro TGF-β administration. Methods Acute renal fibrosis (RF) was induced in mice by unilateral ureteral obstructio...

Full description

Bibliographic Details
Main Authors: Jingyi Zhou, Shuaihui Liu, Luying Guo, Rending Wang, Jianghua Chen, Jia Shen
Format: Article
Language:English
Published: BMC 2020-09-01
Series:BMC Nephrology
Subjects:
CaMKII
ERK
NMDA receptor
Renal fibrosis
Online Access:http://link.springer.com/article/10.1186/s12882-020-02050-x

Internet

http://link.springer.com/article/10.1186/s12882-020-02050-x

Similar Items