Distinct Kinase-Independent Role of RIPK3 in CD11c+ Mononuclear Phagocytes in Cytokine-Induced Tissue Repair

Distinct Kinase-Independent Role of RIPK3 in CD11c+ Mononuclear Phagocytes in Cytokine-Induced Tissue Repair

Receptor interacting protein kinase 3 (RIPK3) induces necroptosis, a type of regulated necrosis, through its kinase domain and receptor interacting protein (RIP) homotypic interaction motif (RHIM). In addition, RIPK3 has been shown to regulate NLRP3 inflammasome and nuclear factor κB (NF-κB) activat...

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Bibliographic Details
Main Authors: Kenta Moriwaki, Sakthi Balaji, John Bertin, Peter J. Gough, Francis Ka-Ming Chan
Format: Article
Language:English
Published: Elsevier 2017-03-01
Series:Cell Reports
Subjects:
necroptosis
IL-23
IL-1b
injury
tissue repair
RIPK3
RHIM
inflammation
colitis
dextran sodium sulfate
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124717301808

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http://www.sciencedirect.com/science/article/pii/S2211124717301808

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