Thrombolytic Therapy During ex-vivo Normothermic Machine Perfusion of Human Livers Reduces Peribiliary Vascular Plexus Injury

Thrombolytic Therapy During ex-vivo Normothermic Machine Perfusion of Human Livers Reduces Peribiliary Vascular Plexus Injury

Background: A major limitation in expanding the use of donation after circulatory death (DCD) livers in transplantation is the increased risk of graft failure secondary to ischemic cholangiopathy. Warm ischemia causes thrombosis and injury to the peribiliary vascular plexus (PVP), which is supplied...

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Bibliographic Details
Main Authors: Omar Haque, Siavash Raigani, Ivy Rosales, Cailah Carroll, Taylor M. Coe, Sofia Baptista, Heidi Yeh, Korkut Uygun, Francis L. Delmonico, James F. Markmann
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-06-01
Series:Frontiers in Surgery
Subjects:
liver transplant
tissue plasminogen activator
normothermic machine liver perfusion
peribiliary vascular plexus
biliary injury
split liver technique
Online Access:https://www.frontiersin.org/articles/10.3389/fsurg.2021.644859/full

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https://www.frontiersin.org/articles/10.3389/fsurg.2021.644859/full

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