Neuronal complexity is attenuated in preclinical models of migraine and restored by HDAC6 inhibition

Neuronal complexity is attenuated in preclinical models of migraine and restored by HDAC6 inhibition

Migraine is the sixth most prevalent disease worldwide but the mechanisms that underlie migraine chronicity are poorly understood. Cytoskeletal flexibility is fundamental to neuronal-plasticity and is dependent on dynamic microtubules. Histone-deacetylase-6 (HDAC6) decreases microtubule dynamics by...

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Bibliographic Details
Main Authors: Zachariah Bertels, Harinder Singh, Isaac Dripps, Kendra Siegersma, Alycia F Tipton, Wiktor D Witkowski, Zoie Sheets, Pal Shah, Catherine Conway, Elizaveta Mangutov, Mei Ao, Valentina Petukhova, Bhargava Karumudi, Pavel A Petukhov, Serapio M Baca, Mark M Rasenick, Amynah A Pradhan
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2021-04-01
Series:eLife
Subjects:
migraine
pain
aura
allodynia
tubulin
cytoskeleton
Online Access:https://elifesciences.org/articles/63076

Internet

https://elifesciences.org/articles/63076

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