Tumour suppressor death-associated protein kinase targets cytoplasmic HIF-1α for Th17 suppression

Tumour suppressor death-associated protein kinase targets cytoplasmic HIF-1α for Th17 suppression

HIF-1α is critical for Th17 differentiation. Here the authors show that DAPK (Death-Associated Protein Kinase) inhibits Th17 differentiation and immunopathology in a mouse model of multiple sclerosis by promoting HIF1-α binding to its negative regulator PHD2.

Bibliographic Details
Main Authors: Ting-Fang Chou, Ya-Ting Chuang, Wan-Chen Hsieh, Pei-Yun Chang, Hsin-Yu Liu, Shu-Ting Mo, Tzu-Sheng Hsu, Shi-Chuen Miaw, Ruey-Hwa Chen, Adi Kimchi, Ming-Zong Lai
Format: Article
Language:English
Published: Nature Publishing Group 2016-06-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/ncomms11904

Internet

https://doi.org/10.1038/ncomms11904

Similar Items