hnRNP A1 and hnRNP F modulate the alternative splicing of exon 11 of the insulin receptor gene.

hnRNP A1 and hnRNP F modulate the alternative splicing of exon 11 of the insulin receptor gene.

Exon 11 of the insulin receptor gene (INSR) is alternatively spliced in a developmentally and tissue-specific manner. Linker scanning mutations in a 5' GA-rich enhancer in intron 10 identified AGGGA sequences that are important for enhancer function. Using RNA-affinity purification and mass spe...

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Bibliographic Details
Main Authors: Indrani Talukdar, Supriya Sen, Rodolfo Urbano, James Thompson, John R Yates, Nicholas J G Webster
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2011-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3223206?pdf=render

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http://europepmc.org/articles/PMC3223206?pdf=render

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