Yap1-2 Isoform Is the Primary Mediator in TGF-β1 Induced EMT in Pancreatic Cancer

Yap1-2 Isoform Is the Primary Mediator in TGF-β1 Induced EMT in Pancreatic Cancer

Pancreatic ductal adenocarcinoma (PDAC) is the most aggressive human malignancy and intrinsically resistant to conventional therapies. YAP1, as a key downstream effector of the Hippo pathway, plays an important role in tumorigenesis including PDAC. Alternative mRNA splicing of YAP1 results in at lea...

Full description

Bibliographic Details
Main Authors: Chao Gao, Mei-Yu Quan, Qian-Jie Chen, Ruo Yang, Yuanyuan Wu, Jia-Yu Liu, Zhong-Yuan Lin, Xue Li, Jue-Ting Cai, Tian-Fang Jiang, Le Xu, Majid Mossahebi-Mohammadi, Qiang Guo, Jin-San Zhang
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-05-01
Series:Frontiers in Oncology
Subjects:
YAP1 isoforms
epithelial-mesenchymal transition
pancreatic cancer
TGF-β
AKT signaling
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2021.649290/full

Internet

https://www.frontiersin.org/articles/10.3389/fonc.2021.649290/full

Similar Items