Use of dual-electron probes reveals the role of ferritin as an iron depot in ex vivo erythropoiesis

Summary: In the finely regulated process of mammalian erythropoiesis, the path of the labile iron pool into mitochondria for heme production is not well understood. Existing models for erythropoiesis do not include a central role for the ubiquitous iron storage protein ferritin; one model proposes t...

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Bibliographic Details
Main Authors: Maria A. Aronova, Seung-Jae Noh, Guofeng Zhang, Colleen Byrnes, Emily Riehm Meier, Young C. Kim, Richard D. Leapman
Format: Article
Language:English
Published: Elsevier 2021-08-01
Series:iScience
Subjects:
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004221008695