Machine learning prediction of cancer cell sensitivity to drugs based on genomic and chemical properties.

Predicting the response of a specific cancer to a therapy is a major goal in modern oncology that should ultimately lead to a personalised treatment. High-throughput screenings of potentially active compounds against a panel of genomically heterogeneous cancer cell lines have unveiled multiple relat...

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Bibliographic Details
Main Authors: Michael P Menden, Francesco Iorio, Mathew Garnett, Ultan McDermott, Cyril H Benes, Pedro J Ballester, Julio Saez-Rodriguez
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3640019?pdf=render