IL17/IL17RA as a Novel Signaling Axis Driving Mesenchymal Stem Cell Therapeutic Function in Experimental Autoimmune Encephalomyelitis

IL17/IL17RA as a Novel Signaling Axis Driving Mesenchymal Stem Cell Therapeutic Function in Experimental Autoimmune Encephalomyelitis

The therapeutic effect of mesenchymal stem cells (MSCs) in multiple sclerosis (MS) and the experimental autoimmune encephalomyelitis (EAE) model has been well described. This effect is, in part, mediated through the inhibition of IL17-producing cells and the generation of regulatory T cells. While p...

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Bibliographic Details
Main Authors: Mónica Kurte, Patricia Luz-Crawford, Ana María Vega-Letter, Rafael A. Contreras, Gautier Tejedor, Roberto Elizondo-Vega, Luna Martinez-Viola, Catalina Fernández-O’Ryan, Fernando E. Figueroa, Christian Jorgensen, Farida Djouad, Flavio Carrión
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-04-01
Series:Frontiers in Immunology
Subjects:
cellular therapy
experimental autoimmune encephalomyelitis
mesenchymal stem cells
IL17
IL17RA
Online Access:http://journal.frontiersin.org/article/10.3389/fimmu.2018.00802/full

Internet

http://journal.frontiersin.org/article/10.3389/fimmu.2018.00802/full

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