Impact of ribonucleotide incorporation by DNA polymerases β and λ on oxidative base excision repair

Impact of ribonucleotide incorporation by DNA polymerases β and λ on oxidative base excision repair

Oxidative stress is a common source of DNA damage and is repaired by the base excision repair machinery, including polymerase beta. Here the authors find that polymerase beta, and to a lesser extent lambda, can mistakenly incorporate ribonucleotides during synthesis.

Bibliographic Details
Main Authors: Emmanuele Crespan, Antonia Furrer, Marcel Rösinger, Federica Bertoletti, Elisa Mentegari, Giulia Chiapparini, Ralph Imhof, Nathalie Ziegler, Shana J. Sturla, Ulrich Hübscher, Barbara van Loon, Giovanni Maga
Format: Article
Language:English
Published: Nature Publishing Group 2016-02-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/ncomms10805

Internet

https://doi.org/10.1038/ncomms10805

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