Enhanced Clearance of Neurotoxic Misfolded Proteins by the Natural Compound Berberine and Its Derivatives

Enhanced Clearance of Neurotoxic Misfolded Proteins by the Natural Compound Berberine and Its Derivatives

Background: Accumulation of misfolded proteins is a common hallmark of several neurodegenerative disorders (NDs) which results from a failure or an impairment of the protein quality control (PQC) system. The PQC system is composed by chaperones and the degradative systems (proteasome and autophagy)....

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Bibliographic Details
Main Authors: Paola Rusmini, Riccardo Cristofani, Barbara Tedesco, Veronica Ferrari, Elio Messi, Margherita Piccolella, Elena Casarotto, Marta Chierichetti, Maria Elena Cicardi, Mariarita Galbiati, Cristina Geroni, Paolo Lombardi, Valeria Crippa, Angelo Poletti
Format: Article
Language:English
Published: MDPI AG 2020-05-01
Series:International Journal of Molecular Sciences
Subjects:
misfolding
neurodegeneration
spinal and bulbar muscular atrophy
protein aggregation
berberine
amyotrophic lateral sclerosis
Online Access:https://www.mdpi.com/1422-0067/21/10/3443

Internet

https://www.mdpi.com/1422-0067/21/10/3443

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