ERK5/BMK1 Is a Novel Target of the Tumor Suppressor VHL: Implication in Clear Cell Renal Carcinoma

ERK5/BMK1 Is a Novel Target of the Tumor Suppressor VHL: Implication in Clear Cell Renal Carcinoma

Extracellular signal-regulated kinase 5 (ERK5), also known as big mitogen-activated protein kinase (MAPK) 1, is implicated in a wide range of biologic processes, which include proliferation or vascularization. Here, we show that ERK5 is degraded through the ubiquitin-proteasome system, in a process...

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Bibliographic Details
Main Authors: Laura Arias-González, Inmaculada Moreno-Gimeno, Antonio Rubio del Campo, Serrano-Oviedo Leticia, María Llanos Valero, Azucena Esparís-Ogando, Miguel Ángel de la Cruz-Morcillo, Pedro Melgar-Rojas, Jesús García-Cano, Francisco José Cimas, María José Ruiz Hidalgo, Alfonso Prado, Juan Luis Callejas-Valera, Syong Hyun Nam-Cha, José Miguel Giménez-Bachs, Antonio S Salinas-Sánchez, Atanasio Pandiella, Luis del Peso, Ricardo Sánchez Prieto
Format: Article
Language:English
Published: Elsevier 2013-06-01
Series:Neoplasia: An International Journal for Oncology Research
Online Access:http://www.sciencedirect.com/science/article/pii/S1476558613801388

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http://www.sciencedirect.com/science/article/pii/S1476558613801388

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