GPER Activation Inhibits Cancer Cell Mechanotransduction and Basement Membrane Invasion via RhoA

GPER Activation Inhibits Cancer Cell Mechanotransduction and Basement Membrane Invasion via RhoA

The invasive properties of cancer cells are intimately linked to their mechanical phenotype, which can be regulated by intracellular biochemical signalling. Cell contractility, induced by mechanotransduction of a stiff fibrotic matrix, and the epithelial−mesenchymal transition (EMT) promot...

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Bibliographic Details
Main Authors: Alistair Rice, Ernesto Cortes, Dariusz Lachowski, Philipp Oertle, Carlos Matellan, Stephen D. Thorpe, Ritobrata Ghose, Haiyun Wang, David A. Lee, Marija Plodinec, Armando E. del Río Hernández
Format: Article
Language:English
Published: MDPI AG 2020-01-01
Series:Cancers
Subjects:
cancer biomechanics
metastasis
g protein-coupled receptors
tumour microenvironment
Online Access:https://www.mdpi.com/2072-6694/12/2/289

Internet

https://www.mdpi.com/2072-6694/12/2/289

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