Glucose-sensing microRNA-21 disrupts ROS homeostasis and impairs antioxidant responses in cellular glucose variability

Glucose-sensing microRNA-21 disrupts ROS homeostasis and impairs antioxidant responses in cellular glucose variability

Abstract Background Antioxidant enzymes play a fundamental role in counteracting oxidative stress induced by high glucose. Although mitochondrial superoxide dismutase (SOD2) is the principal defence against the toxicity of superoxide anions, the mechanism of its inactivation in diabetic subjects is...

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Bibliographic Details
Main Authors: Lucia La Sala, Simona Mrakic-Sposta, Stefano Micheloni, Francesco Prattichizzo, Antonio Ceriello
Format: Article
Language:English
Published: BMC 2018-07-01
Series:Cardiovascular Diabetology
Subjects:
miR-21
ROS homeostasis
KRIT1
SOD2
Superoxide anion
Mitochondrial dysfunction
Online Access:http://link.springer.com/article/10.1186/s12933-018-0748-2

Internet

http://link.springer.com/article/10.1186/s12933-018-0748-2

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