Multiscale molecular profiling of pathological bone resolves sexually dimorphic control of extracellular matrix composition

Multiscale molecular profiling of pathological bone resolves sexually dimorphic control of extracellular matrix composition

Collagen assembly during development is essential for successful matrix mineralisation, which determines bone quality and mechanocompetence. However, the biochemical and structural perturbations that drive pathological skeletal collagen configuration remain unclear. Deletion of vascular endothelial...

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Bibliographic Details
Main Authors: Aikta Sharma, Alice Goring, Peter B. Johnson, Roger J. H. Emery, Eric Hesse, Alan Boyde, Bjorn R. Olsen, Andrew A. Pitsillides, Richard O. C. Oreffo, Sumeet Mahajan, Claire E. Clarkin
Format: Article
Language:English
Published: The Company of Biologists 2021-03-01
Series:Disease Models & Mechanisms
Subjects:
polarisation-resolved second-harmonic generation
raman spectroscopy
sexual dimorphism
extracellular matrix
collagen
vegf
Online Access:http://dmm.biologists.org/content/14/3/dmm048116

Internet

http://dmm.biologists.org/content/14/3/dmm048116

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