Multi-electrode array study of neuronal cultures expressing nicotinic β2-V287L subunits, linked to autosomal dominant nocturnal frontal lobe epilepsy. An in vitro model of spontaneous epilepsy.

Multi-electrode array study of neuronal cultures expressing nicotinic β2-V287L subunits, linked to autosomal dominant nocturnal frontal lobe epilepsy. An in vitro model of spontaneous epilepsy.

Autosomal dominant nocturnal frontal lobe epilepsy (ADNFLE) is a partial sleep-related epilepsy which can be caused by mutant neuronal nicotinic acetylcholine receptors (nAChR). We applied multi-electrode array (MEA) recording methods to study the spontaneous firing activity of neocortical cultures...

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Bibliographic Details
Main Authors: Francesca eGullo, Irene eManfredi, Marzia eLecchi, Giorgio eCasari, Enzo eWanke, Andrea eBecchetti
Format: Article
Language:English
Published: Frontiers Media S.A. 2014-07-01
Series:Frontiers in Neural Circuits
Subjects:
Carbamazepine
Epilepsy
Frontal Lobe
MEA
mouse models
nAChR
Online Access:http://journal.frontiersin.org/Journal/10.3389/fncir.2014.00087/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fncir.2014.00087/full

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