Metformin suppresses phenylephrine-induced hypertrophic responses by inhibiting p300-HAT activity in cardiomyocytes

Metformin suppresses phenylephrine-induced hypertrophic responses by inhibiting p300-HAT activity in cardiomyocytes

Introduction: Heart failure is the final pathway for a wide spectrum of myocardial stress, including hypertension and myocardial infarction. However, the potential effects of metformin on cardiac hypertrophy are still unclear. Purpose: The purpose of this study was to investigate whether metformin l...

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Bibliographic Details
Main Authors: Yoichi Sunagawa, Kiyotaka Shimizu, Ayumi Katayama, Masafumi Funamoto, Kana Shimizu, Sari Nurmila, Satoshi Shimizu, Yusuke Miyazaki, Yasufumi Katanasaka, Koji Hasegawa, Tatsuya Morimoto
Format: Article
Language:English
Published: Elsevier 2021-10-01
Series:Journal of Pharmacological Sciences
Subjects:
Metformin
p300
Cardiomyocyte
Hypertrophy
Histone acetyltransferase
Online Access:http://www.sciencedirect.com/science/article/pii/S1347861321000682

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http://www.sciencedirect.com/science/article/pii/S1347861321000682

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