Genomic Mapping Identifies Mutations in RYR2 and AHNAK as Associated with Favorable Outcome in Basal-Like Breast Tumors Expressing PD1/PD-L1

Genomic Mapping Identifies Mutations in RYR2 and AHNAK as Associated with Favorable Outcome in Basal-Like Breast Tumors Expressing PD1/PD-L1

Treatment with anti-PD-L1 antibodies has shown efficacy in basal-like breast cancer. In this context, identification of pre-activated immune tumors is a main goal. Here we explore mutations in PD1 and PD-L1 high-expressing tumors to identify genomic correlates associated with outcome. To do so, RNA-...

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Bibliographic Details
Main Authors: Francisco J. Cimas, Arancha Manzano, Mariona Baliu-Piqué, Elena García-Gil, Pedro Pérez-Segura, Ádám Nagy, Atanasio Pandiella, Balázs Győrffy, Alberto Ocana
Format: Article
Language:English
Published: MDPI AG 2020-08-01
Series:Cancers
Subjects:
RYR2
AHNAK
Basal-like tumors
PD-L1
immunotherapy
Online Access:https://www.mdpi.com/2072-6694/12/8/2243

Internet

https://www.mdpi.com/2072-6694/12/8/2243

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