Exosomal miR-196a derived from cancer-associated fibroblasts confers cisplatin resistance in head and neck cancer through targeting CDKN1B and ING5

Exosomal miR-196a derived from cancer-associated fibroblasts confers cisplatin resistance in head and neck cancer through targeting CDKN1B and ING5

Abstract Background Cisplatin resistance is a major challenge for advanced head and neck cancer (HNC). Understanding the underlying mechanisms and developing effective strategies against cisplatin resistance are highly desired in the clinic. However, how tumor stroma modulates HNC growth and chemore...

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Bibliographic Details
Main Authors: Xing Qin, Haiyan Guo, Xiaoning Wang, Xueqin Zhu, Ming Yan, Xu Wang, Qin Xu, Jianbo Shi, Eryi Lu, Wantao Chen, Jianjun Zhang
Format: Article
Language:English
Published: BMC 2019-01-01
Series:Genome Biology
Subjects:
Exosome
Cancer-associated fibroblasts
miR-196a
Cisplatin resistance
Head and neck cancer
CDKN1B
Online Access:http://link.springer.com/article/10.1186/s13059-018-1604-0

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http://link.springer.com/article/10.1186/s13059-018-1604-0

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