From association to mechanism in complex disease genetics: the role of the 3D genome
Abstract Genome-wide association studies (GWAS) and fine mapping studies in autoimmune diseases have identified thousands of genetic variants, the majority of which are located in non-protein-coding enhancer regions. Enhancers function within the context of the three-dimensional (3D) genome to form...
Main Authors: | , , , |
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Format: | Article |
Language: | English |
Published: |
BMC
2018-09-01
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Series: | Arthritis Research & Therapy |
Subjects: | |
Online Access: | http://link.springer.com/article/10.1186/s13075-018-1721-x |