From association to mechanism in complex disease genetics: the role of the 3D genome

From association to mechanism in complex disease genetics: the role of the 3D genome

Abstract Genome-wide association studies (GWAS) and fine mapping studies in autoimmune diseases have identified thousands of genetic variants, the majority of which are located in non-protein-coding enhancer regions. Enhancers function within the context of the three-dimensional (3D) genome to form...

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Bibliographic Details
Main Authors: Yao Fu, Kandice L Tessneer, Chuang Li, Patrick M Gaffney
Format: Article
Language:English
Published: BMC 2018-09-01
Series:Arthritis Research & Therapy
Subjects:
Autoimmune disease
3D genome
Chromatin conformation
Complex genetic disease
DNA looping
Functional genomics
Online Access:http://link.springer.com/article/10.1186/s13075-018-1721-x

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http://link.springer.com/article/10.1186/s13075-018-1721-x

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