Novel PGC-1α/ATF5 Axis Partly Activates UPRmt and Mediates Cardioprotective Role of Tetrahydrocurcumin in Pathological Cardiac Hypertrophy

Novel PGC-1α/ATF5 Axis Partly Activates UPRmt and Mediates Cardioprotective Role of Tetrahydrocurcumin in Pathological Cardiac Hypertrophy

Mitochondrial unfolding protein response (UPRmt) effectively resists the pathological cardiac hypertrophy and improves the mitochondrial function. However, the specific activation mechanism and drugs that can effectively activate UPRmt in the cardiac muscle are yet to be elucidated. The aim of this...

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Bibliographic Details
Main Authors: Bing Zhang, Yanzhen Tan, Zhengbin Zhang, Pan Feng, Wenyuan Ding, Qian Wang, Hongliang Liang, Weixun Duan, Xiaowu Wang, Shiqiang Yu, Jincheng Liu, Dinghua Yi, Yang Sun, Wei Yi
Format: Article
Language:English
Published: Hindawi Limited 2020-01-01
Series:Oxidative Medicine and Cellular Longevity
Online Access:http://dx.doi.org/10.1155/2020/9187065

Internet

http://dx.doi.org/10.1155/2020/9187065

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