Novel PGC-1α/ATF5 Axis Partly Activates UPRmt and Mediates Cardioprotective Role of Tetrahydrocurcumin in Pathological Cardiac Hypertrophy
Mitochondrial unfolding protein response (UPRmt) effectively resists the pathological cardiac hypertrophy and improves the mitochondrial function. However, the specific activation mechanism and drugs that can effectively activate UPRmt in the cardiac muscle are yet to be elucidated. The aim of this...
Main Authors: | Bing Zhang, Yanzhen Tan, Zhengbin Zhang, Pan Feng, Wenyuan Ding, Qian Wang, Hongliang Liang, Weixun Duan, Xiaowu Wang, Shiqiang Yu, Jincheng Liu, Dinghua Yi, Yang Sun, Wei Yi |
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Format: | Article |
Language: | English |
Published: |
Hindawi Limited
2020-01-01
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Series: | Oxidative Medicine and Cellular Longevity |
Online Access: | http://dx.doi.org/10.1155/2020/9187065 |
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