Mechanism of nucleic acid unwinding by SARS-CoV helicase.

Mechanism of nucleic acid unwinding by SARS-CoV helicase.

The non-structural protein 13 (nsp13) of Severe Acute Respiratory Syndrome Coronavirus (SARS-CoV) is a helicase that separates double-stranded RNA (dsRNA) or DNA (dsDNA) with a 5' → 3' polarity, using the energy of nucleotide hydrolysis. We determined the minimal mechanism of helicase func...

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Bibliographic Details
Main Authors: Adeyemi O Adedeji, Bruno Marchand, Aartjan J W Te Velthuis, Eric J Snijder, Susan Weiss, Robert L Eoff, Kamalendra Singh, Stefan G Sarafianos
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3352918?pdf=render

Internet

http://europepmc.org/articles/PMC3352918?pdf=render

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