Dynamics of plasma biomarkers in Down syndrome: the relative levels of Aβ42 decrease with age, whereas NT1 tau and NfL increase

Dynamics of plasma biomarkers in Down syndrome: the relative levels of Aβ42 decrease with age, whereas NT1 tau and NfL increase

Abstract Background Down syndrome (DS) is the most common genetic cause of Alzheimer’s disease (AD), but diagnosis of AD in DS is challenging due to the intellectual disability which accompanies DS. When disease-modifying agents for AD are approved, reliable biomarkers will be required to identify w...

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Bibliographic Details
Main Authors: David Mengel, Wen Liu, Robert J. Glynn, Dennis J. Selkoe, Andre Strydom, Florence Lai, H. Diana Rosas, Amy Torres, Vasiliki Patsiogiannis, Brian Skotko, Dominic M. Walsh
Format: Article
Language:English
Published: BMC 2020-03-01
Series:Alzheimer’s Research & Therapy
Subjects:
Alzheimer’s disease
Amyloid
Down syndrome
Dementia
Neurofilament light
Simoa
Online Access:http://link.springer.com/article/10.1186/s13195-020-00593-7

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http://link.springer.com/article/10.1186/s13195-020-00593-7

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