Boosting Natural Killer Cell-Mediated Targeting of Sarcoma Through DNAM-1 and NKG2D

Boosting Natural Killer Cell-Mediated Targeting of Sarcoma Through DNAM-1 and NKG2D

Sarcomas are malignancies of mesenchymal origin that occur in bone and soft tissues. Many are chemo- and radiotherapy resistant, thus conventional treatments fail to increase overall survival. Natural Killer (NK) cells exert anti-tumor activity upon detection of a complex array of tumor ligands, but...

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Bibliographic Details
Main Authors: Ece Canan Sayitoglu, Anna-Maria Georgoudaki, Michael Chrobok, Didem Ozkazanc, Benjamin J. Josey, Muhammad Arif, Kim Kusser, Michelle Hartman, Tamara M. Chinn, Renee Potens, Cevriye Pamukcu, Robin Krueger, Cheng Zhang, Adil Mardinoglu, Evren Alici, Harry Thomas Temple, Tolga Sutlu, Adil Doganay Duru
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-01-01
Series:Frontiers in Immunology
Subjects:
cancer immunotherapy
cancer immunology
sarcoma
natural killer (NK) cell
DNAM-1 (CD226)
NKG2D (Natural killer group 2 member D)
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2020.00040/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2020.00040/full

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