METTL3 facilitates tumor progression via an m6A-IGF2BP2-dependent mechanism in colorectal carcinoma

METTL3 facilitates tumor progression via an m6A-IGF2BP2-dependent mechanism in colorectal carcinoma

Abstract Background Colorectal carcinoma (CRC) is one of the most common malignant tumors, and its main cause of death is tumor metastasis. RNA N6-methyladenosine (m6A) is an emerging regulatory mechanism for gene expression and methyltransferase-like 3 (METTL3) participates in tumor progression in...

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Bibliographic Details
Main Authors: Ting Li, Pei-Shan Hu, Zhixiang Zuo, Jin-Fei Lin, Xingyang Li, Qi-Nian Wu, Zhan-Hong Chen, Zhao-Lei Zeng, Feng Wang, Jian Zheng, Demeng Chen, Bo Li, Tie-Bang Kang, Dan Xie, Dongxin Lin, Huai-Qiang Ju, Rui-Hua Xu
Format: Article
Language:English
Published: BMC 2019-06-01
Series:Molecular Cancer
Subjects:
Colorectal cancer
N6-methyladenosine (m6A)
METTL3
SOX2
IGF2BP2
Online Access:http://link.springer.com/article/10.1186/s12943-019-1038-7

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http://link.springer.com/article/10.1186/s12943-019-1038-7

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