Coeloglossum viride var. bracteatum extract improves cognitive deficits by restoring BDNF, FGF2 levels and suppressing RIP1/RIP3/MLKL-mediated neuroinflammation in a 5xFAD mouse model of Alzheimer’s disease

Coeloglossum viride var. bracteatum extract improves cognitive deficits by restoring BDNF, FGF2 levels and suppressing RIP1/RIP3/MLKL-mediated neuroinflammation in a 5xFAD mouse model of Alzheimer’s disease

The neuroprotective effects of Coeloglossum viride var. bracteatum extract (CE) was investigated in a mouse model of AD. We found that CE improved cognitive deficits in 5xFAD mice in MWM and Y-maze behavioral tests. Also, antioxidant levels in serum and brain were normalized and peroxidation product...

Full description

Bibliographic Details
Main Authors: Xi-Xi Li, Zhe-Ping Cai, Xiu-Yuan Lang, Rui-Yuan Pan, Teng-Teng Ren, Rongfeng Lan, Xiao-Yan Qin
Format: Article
Language:English
Published: Elsevier 2021-10-01
Series:Journal of Functional Foods
Subjects:
Aβ
BDNF
IBA1
Necroptosis
TBK1
Y-maze test
Online Access:http://www.sciencedirect.com/science/article/pii/S1756464621002619

Internet

http://www.sciencedirect.com/science/article/pii/S1756464621002619

Similar Items