Perampanel Add-on to Standard Radiochemotherapy in vivo Promotes Neuroprotection in a Rodent F98 Glioma Model

Perampanel Add-on to Standard Radiochemotherapy in vivo Promotes Neuroprotection in a Rodent F98 Glioma Model

An abnormal glutamate signaling of glioblastoma may contribute to both tumor progression and the generation of glioma-associated epileptic seizures. We hypothesized that the AMPA receptor antagonist perampanel (PER) could attenuate tumor growth and epileptic events. F98 glioma cells, grown orthotopi...

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Bibliographic Details
Main Authors: Falko Lange, Jens Hartung, Clara Liebelt, Julius Boisserée, Tobias Resch, Katrin Porath, Julia Hörnschemeyer, Gesine Reichart, Tina Sellmann, Valentin Neubert, Stephan Kriesen, Guido Hildebrandt, Elisabeth Schültke, Rüdiger Köhling, Timo Kirschstein
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-11-01
Series:Frontiers in Neuroscience
Subjects:
epilepsy
glioblastoma
glioma
perampanel
radiochemotherapy
glutamate
Online Access:https://www.frontiersin.org/articles/10.3389/fnins.2020.598266/full

Internet

https://www.frontiersin.org/articles/10.3389/fnins.2020.598266/full

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